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Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase

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Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase
Identifiers
EC no.2.4.1.287
Databases
IntEnzIntEnz view
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Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase (EC 2.4.1.287, arabinogalactan galactofuranosyl transferase 1, GlfT1) is an enzyme with systematic name UDP-alpha-D-galactofuranose:alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-beta/4-beta-galactofuranosyltransferase.[1][2] This enzyme catalyses the following chemical reaction

2 UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 2 UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol (overall reaction)
(1a) UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol UDP + beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
(1b) UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol

This enzyme is isolated from Mycobacterium tuberculosis and M. smegmatis.

References

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  1. ^ Mikusová K, Belánová M, Korduláková J, Honda K, McNeil MR, Mahapatra S, Crick DC, Brennan PJ (September 2006). "Identification of a novel galactosyl transferase involved in biosynthesis of the mycobacterial cell wall". Journal of Bacteriology. 188 (18): 6592–8. doi:10.1128/JB.00489-06. PMC 1595490. PMID 16952951.
  2. ^ Belánová M, Dianisková P, Brennan PJ, Completo GC, Rose NL, Lowary TL, Mikusová K (February 2008). "Galactosyl transferases in mycobacterial cell wall synthesis". Journal of Bacteriology. 190 (3): 1141–5. doi:10.1128/JB.01326-07. PMC 2223555. PMID 18055597.
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